2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Factor Xa

Factor Xa

Fxa

Factor Xa

Related Products

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Factor Xa, a trypsin-like serine protease, is situated at the critical juncture between the intrinsic and extrinsic pathways, catalyzing the conversion of prothrombin to thrombin, and hence plays a pivotal role in the final common pathway of the cascade and has become an important target in the discovery and development of new anticoagulants. Factor Xa is a key protease of the coagulation pathway whose activity is known to be in part modulated by binding to factor Va and sodium ions.

Blood coagulation involves a complex cascade of enzymatic reactions, ultimately generating fibrin, the basis of all blood clots. This cascade is comprised of two arms, the intrinsic and extrinsic pathways which converge at factor Xa to form the common pathway. Factor Xa activates prothrombin to thrombin, which in turn catalyzes the conversion of fibrinogen to fibrin.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-125505
    BI-11634
    		Inhibitor
    BI-11634 is a factor Xa inhibitor. BI-11634 is metabolized by CYP3A4 to form one major metabolite and this reaction is inhibited by Quinidine (HY-B1751H) with a Ki of 7 µM.
    BI-11634
  • HY-10264BR
    Edoxaban tosylate monohydrate (Standard)
    		Inhibitor
    Edoxaban tosylate monohydrate (Standard) is the analytical standard of Edoxaban tosylate monohydrate (HY-10264B). This product is intended for research and analytical applications. Edoxaban (DU-176b) monohydrate is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Kis of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban monohydrate exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban monohydrate can be used for preventing thromboembolic disease research.
    Edoxaban tosylate monohydrate (Standard)
  • HY-B0385R
    Gabexate mesylate (Standard)
    		Inhibitor
    Gabexate (mesylate) (Standard) is the analytical standard of Gabexate (mesylate). This product is intended for research and analytical applications. Gabexate mesylate (FOY) is is a competitive and non-antigenic synthetic inhibitor of trypsin-like serine proteinases. Gabexate mesylate inhibits human thrombin, urokinase, plasmin, and Factor Xa with Kis of 0.97, 1.3, 1.6, and 8.5 μM, respectively. Gabexate mesylate binds to human and bovine tryptase with Kis of 3.4 nM and 18 μM, respectively. Gabexate mesylate exerts an anticoagulant effect on the clotting activity of thrombin and has anti-inflammatory effect by viainhibition of NF-κB, proinflammatory cytokines, and nitric oxide. Gabexate mesylate is used for pancreatitis and disseminated intravascular coagulation.
    Gabexate mesylate (Standard)
  • HY-157547
    FXIa-IN-14
    		Inhibitor
    FXIa-IN-14 (Compound 14c) is a FXIa inhibitor with an IC50 value of 15 nM.
    FXIa-IN-14
  • HY-19866
    Darexaban glucuronide
    		Activator
    Darexaban glucuronide (YM-222714) is a active metabolite of darexaban (YM150). Darexaban glucuronide has an oral activity and antithrombotic effect.
    Darexaban glucuronide
  • HY-121244
    Coumafuryl
    		Inhibitor
    Coumafuryl is a kind of coumarin rodenticide. Coumafuryl inhibits the metabolic cycle of vitamin K that causes the interference with protein biosynthesis of vitamin K-dependent coagulant factors (II, VII, IX, and X factors) in the liver.
    Coumafuryl
  • HY-10268S1
    Betrixaban-dsub>4
    		Inhibitor
    Betrixaban-d4 (PRT054021-d4) is deuterium labeled Betrixaban. Betrixaban (PRT054021) is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor with an IC50 of 1.5 nM. Betrixaban shows antithrombotic effect.
    Betrixaban-dsub>4</sub>
  • HY-123356
    EMD-503982
    		Inhibitor
    EMD-503982 is an orally available FXa inhibitor.
    EMD-503982
  • HY-179708
    Cbz-QFR-kbt
    		Inhibitor
    Cbz-QFR-kbt is a ketone-based benzothiazole ketone inhibitor of TMPRSS2, with an IC50 value of 0.42 nM. Cbz-QFR-kbt also has inhibitory activity against Matriptase, Hepsin, HGFA, and Factor Xa, with IC50 values of 1, 1.3, 85, and 85 nM respectively. Cbz-QFR-kbt shows significant inhibitory effects against SARS-CoV-2 and H1N1 (IC50 = 60 nM). Cbz-QFR-kbt can be used in antiviral research.
    Cbz-QFR-kbt
  • HY-180217
    WGU55
    		Inhibitor
    WGU55 is a selective and potent reversible type II transmembrane serine protease TMPRSS6 inhibitor with a Ki of 12.15 nM. WGU55 inhibits TMPRSS6 activity with an IC50 of 138 nMin KEK293 cells. WGU55 has a Ki of 3510 nM (SI = 289) against the homologous protease matriptase and a Ki of 5.2 μM against the coagulation key protease Factor Xa. WGU55 can be used for the research of iron overload related diseases, such as hereditary hemochromatosis.
    WGU55
  • HY-10280S
    YM-60828-d3
    		Inhibitor
    YM-60828-d3 is the deuterium labeled YM-60828 (HY-10280). YM-60828 is an orally active, selective and competitive factor Xa inhibitor with a Ki of 1.3 nM and an IC50 of 2.3 nM. YM-60828 inhibits thrombus formation and platelet aggregation. YM-60828 can be used for the research of venous thrombosis, arterial thrombosis, and thromboembolic disorders.
    YM-60828-d<sub>3</sub>
  • HY-N13957
    Bacithrocin C
    		Inhibitor
    Bacithrocin C is a thrombin inhibitor that inhibits thrombin, factor Xa, trypsin and Papain with IC50s of 80 μM, 15 μM, 1.3 μM, and 0.02 μM, respectively.
    Bacithrocin C
  • HY-76948R
    5-R-Rivaroxaban (Standard)
    		Inhibitor
    5-R-Rivaroxaban (Standard) is the analytical standard of 5-R-Rivaroxaban. This product is intended for research and analytical applications. 5-R-Rivaroxaban is (R)-enantiomer of Rivaroxaban. Rivaroxaban (BAY 59-7939) is a highly potent and selective, direct Factor Xa (FXa) inhibitor, achieving a strong gain in anti-FXa potency (IC50 0.7 nM; Ki 0.4 nM).
    5-R-Rivaroxaban (Standard)
  • HY-118803
    AS1468240
    		Inhibitor
    AS1468240 is an orally active inhibitor for anticoagulant factor Xa (fXa), that inhibits human fXa with IC50 of 8.7 nM. AS1468240 prolongs the coagulation time in mice.
    AS1468240
  • HY-166257
    Lyso-sulfatide (bovine)
    		Inhibitor
    Lyso-sulfatide (bovine) is a phospholipid component derived from sphingolipid catabolism and a potent factor Xa inhibitor and anticoagulant. Lyso-sulfatide (bovine) binds directly to factor Xa and inhibits prothrombin activation mediated by the prothrombinase complex, thereby prolonging factor Xa-induced plasma clotting time and suppressing thrombin generation. Lyso-sulfatide (bovine) serves as a reliable lipid membrane mimic for studying cell membrane structure, function, and molecular interactions.
    Lyso-sulfatide (bovine)
  • HY-P991006
    Lofacimig
    HY-P991006 is an FXI/PTA-targeting VH-VH-G1(h-CH2-CH3) dimer type bispecific antibody.
    Lofacimig
  • HY-N13955
    Bacithrocin B
    		Inhibitor
    Bacithrocin B is a thrombin inhibitor that inhibits thrombin, factor Xa, trypsin and Papain with IC50s of 84 μM, 17 μM, 1.7 μM, and 0.02 μM, respectively.
    Bacithrocin B
  • HY-179017
    FXa-IN-2
    		Inhibitor
    FXa-IN-2 (Compound K3) is a reversible FXainhibitor, with an IC50 value of 45.08 μM. FXa-IN-2 can be used in the research of thromboembolic diseases.
    FXa-IN-2
  • HY-76835R
    5-Chlorothiophene-2-carboxylic acid (Standard)
    5-Chlorothiophene-2-carboxylic acid (Standard) is the analytical standard of 5-Chlorothiophene-2-carboxylic acid. This product is intended for research and analytical applications. 5-Chlorothiophene-2-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    5-Chlorothiophene-2-carboxylic acid (Standard)
  • HY-10725
    Tanogitran
    		Inhibitor
    Tanogitran is a dual inhibitor targeting Factor Xa and thrombin (thrombin), with Ki values of 26 and 2.7 nM, respectively. Tanogitran exhibits anticoagulant activity and can be used for research in thrombotic diseases.
    Tanogitran
Cat. No. Product Name / Synonyms Application Reactivity